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[知识] 板块主题窝 --- 生物和化学制药

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发表于 2009-3-9 07:29 AM | 显示全部楼层


Merk will buy Schering.
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发表于 2009-3-9 08:37 AM | 显示全部楼层
161# 笑口常开

I wasn't woke up till hearing this news this morning while still in bed. I has been very confident that my job is secure in the coming three or four years. However, this news certainly adds uncertainty in my job. In this slow economy, it seems nothing is certain! Good luck to us all!
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发表于 2009-3-9 08:39 AM | 显示全部楼层
Hope this news will bring the market up like Pfizer's news (acquire Wyeth) did a few weeks ago.
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 楼主| 发表于 2009-3-9 09:31 AM | 显示全部楼层
券商瑞信指出,美国的卫生保健改革对于所有的医疗和设施供应商而言都是一个挑战,
不论长期还是短期。券商表示医疗科技板块并不是改革的直接目标,但是目前的环
境并不是十分有利。券商相信政府加强对于医疗科技的管制是一个利空消息,因为
产品的扩大利用将会被更加严格的管制所抵消。券商相信,目前的估值反映了不确
定性,在细节出台之前,股价不大可能会出现反弹。券商认为,目前木有相对优势
的股票包括EW, BDX, COV, BAX和BCR。将会受到较多不利影响的股票包括BSX, STJ,
MDT, SYK, 和ZMH。
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发表于 2009-3-9 09:36 AM | 显示全部楼层
161# 笑口常开

Good luck to you!
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 楼主| 发表于 2009-3-9 12:15 PM | 显示全部楼层
券商Deutsche Bank认为,奥巴马的卫生保健改革会有几个利好影响。统一综合预算
协调法案的扩大会缓解因为失业率上升造成了药物使用率的下降。同时,宣导使用
E-Rx会帮助处方药集采商(PBM)更好的监控,迫使病人服从,推动利润上升。生物
仿制药可能立法很受欢迎,几周内通过的可能性很大。生物仿制药会从2011年到更
久为PBM提供更多的就会。最后,担心卫生保健补偿会减少的猜测是没有根据的,因
为MedcoHealth Solutions(MHS)和 Express Scripts(ESRX)最近都获得了大量的补
偿。
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 楼主| 发表于 2009-3-9 01:35 PM | 显示全部楼层
Investing in Pharmaceuticals Via ETF

I have been thinking about shifting some funds into pharmaceutical stocks for several reasons. Here’s my analysis to date:
• non-cyclical growth stocks like the pharmaceuticals can grow earnings and dividends through boom and bust – they are the kind of stocks one can put away for a decade and forget about
• because of concerns over legal issues, patent expirations, and product-pipelines in recent years, valuations are low -- BCA Research says that analyst earnings expectations for U.S. pharmaceuticals are at a historic low relative to S&P 500 earnings projections
• yet, a recent industry report by Standard & Poor says much of the shortfall from patent expirations will be offset by new drugs
• if economic growth slows down (of which there are signs), defensive stocks will gain favor over riskier plays in the market
• during the lackluster environment of recent years, U.S. pharma has responded by cutting costs -- while maintaining R&D and balance sheet strength (which also supports stock buybacks)
• pharmaceuticals in Europe and elsewhere have enjoyed good share gains in recent years, so U.S. peers have some catching up to do
• pharma is one of the strongest industries around: it has one of the highest returns on investment capital (35%) and best company survivorship rates.
• demographics (aging of baby boomers and rising middle class in emerging countries) are supportive


For North American investors, there appear to be four exchange traded funds (ETFs) and one HOLDRs covering pharmaceutical stocks:

Pharmaceutical HOLDRs (PPH)
iShares DJ US Pharmaceuticals (IHE)
PowerShares Dynamic Pharmaceuticals (PJP)
SPDR Pharmaceuticals (XPH)
iShares S&P Global Health Care (IXJ)

The HOLDRs does not track an index; it is an unadjusted basket of stocks that was selected by the fund’s founders to represent the U.S. pharmaceutical sector. The iShares Global Health Care fund includes some non-pharma health care companies but nevertheless retains a 75% exposure (and adds geographical diversification).

The Pharmaceutical HOLDRs stands out from the others in many ways:

• annual management cost much lower
• dividend yield much higher
• average daily trading volume way ahead
• option trading noticeably more liquid too.


Perhaps one negative of the HOLDRs for small investors is the requirement to buy in board lots only. With the current price at $75.50, that means there is a minimum purchase requirement of $7,500.

Another drawback might be the concentration of holdings: with no rebalancing or replacement of defunct companies over the six years since inception, the top ten stocks now claim 91% of the weights – with Johnson & Johnson and Pfizer at 21% each (other ETFs range around the 50% mark). This could make the HOLDRS more vulnerable to extreme moves by one or two stocks; volatility might be more of an issue.

Valuations for the North American pharmaceutical sector have ebbed because of concerns over lawsuits, patent expirations, and product-pipelines. Indeed, BCA Research notes that analyst earnings expectations are currently at a historic low relative to S&P 500 earnings projections. There is also a lot of catching up to do with the gains in the share prices of non-U.S. pharmaceuticals.

U.S. pharma has responded to the lackluster environment of recent years by cutting costs (while maintaining R&D and balance sheet strength). And a report by Standard & Poor says much of the shortfall from patent expirations will be offset by new drugs. Lastly, non-cyclical growth stocks like the pharma group should gain favor as global growth wanes.

There are four exchange traded funds (ETFs) and one HOLDR covering the sector. From the table below, it is apparent the Pharmaceutical HOLDR stands out in terms of cost, liquidity, and yield.

Perhaps one negative of the HOLDR is the requirement to buy in board lots. Another might be concentration in holdings: with no rebalancing or replacement of companies over the six years since inception, the top ten stocks now claim 91% of the weights – with Johnson & Johnson and Pfizer at 21% each.
pharmaetf.jpg
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 楼主| 发表于 2009-3-11 12:23 PM | 显示全部楼层
众议院能源和商业委员会主席Waxman提议,允许FDA批准生物科技药物仿制药。
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 楼主| 发表于 2009-3-11 12:52 PM | 显示全部楼层
众议院能源和商业委员会主席Waxman提议,允许FDA批准生物科技药物仿制药。
spy2009 发表于 2009-3-11 13:23


mab老大,如果FDA批准生物科技药物仿制药,对国内生物制药公司是好消息?对美国生物制药公司巨头AMGN和DNA来说,是坏消息?

Thanks!
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发表于 2009-3-11 03:04 PM | 显示全部楼层
First, I am not 老大, please do not call me that.
Just my understanding, maybe wrong.

It will be easy for FDA to approve smaller therapeutic protein (around 5-10kDa), such as Epo from Amgen, because their structure is simple compared to large molecule such as antibody (150kDa). In addition, some antibodies utilize glycosylation to function such as Herceptin. Different manufactures may produce different antibodies using the same DNA sequence. Even legislature pass the bill, it may take FDA a long time to have a guidance available.  

DNA is going to be bought by Roche Holding, so it does not matter any more. For amgen, I guess market has discount the factor because of their Epo. I personally think Amgen would be a good investment in a long run since DNA is gone.

In term of the impact on Chinese biotech stock, I honestly do not know much. Do you have list of Chinese biotech companies, I may spend some time to investigate them. For a long run, I believe biologic follow-on will be a big hit in China.
Thank you as well!
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 楼主| 发表于 2009-3-11 03:52 PM | 显示全部楼层
偶只关心,在美国上市的中国股票:SSRX, SVA, TBV

一定有偶不知道的,哪位邻居知道,请帮忙找一找?
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发表于 2009-3-12 03:00 AM | 显示全部楼层
70# spy2009


MR还可以关注,CMED就太忽悠了
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发表于 2009-3-12 03:49 AM | 显示全部楼层
wow!
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发表于 2009-3-12 04:43 AM | 显示全部楼层
偶只关心,在美国上市的中国股票:SSRX, SVA, TBV

一定有偶不知道的,哪位邻居知道,请帮忙找一找?
spy2009 发表于 2009-3-11 04:52 PM


CSKI  China Sky One Med Inc (NASDAQ GM)  today @ 11.09

SCR  Simcere Pharmaceutical Group (NYSE)   today @ 5.52

$6 China Biotech Stock to Hit $10!
By StockGumshoe ⋅ January 26, 2009


This ad came in fast and hard over the weekend, behind the full marketing might of the folks at Investorplace in service of Asia Edge, Robert Hsu’s more expensive pan-Asia newsletter.

And it looks like they’re using some of the tested and (one assumes) successful marketing strategies that got Louis Navellier a lot of attention in this space last Summer (same publisher, naturally). As Navellier sent out ad after ad over the summer that promised huge returns in a matter of weeks for stocks like Gran Tierra Energy and Fuel Systems Solutions, so too Hsu is making bold short-term predictions today.

He’s found a Chinese healthcare stock that he thinks will go from the current six dollars up to ten bucks … the short term call is that Hsu says “I’m targeting 30% profit in the weeks ahead.”

And just to make sure you get your subscription in quickly, he tells us that the stock will be released over the weekend (so it’s out now, that means — the Gumshoe’s gotta sleep, after all) … and that …

    “The Big Money Will Be Made in the Next 14 Days”

And of course, one of my favorite promises, also used often by Navellier: “you’ll thank me” — or, more specifically …

    “Buy this one today and I guarantee you’ll thank me a thousand times by April 15th.”

So, whether or not we believe him that this stock is going to shoot forward in the weeks ahead, it can’t hurt to figure out what it is, right? At least, it can’t hurt if it’s free … which is probably why you’ve read this far. The Gumshoe has a grating habit of speaking in the third person, but he’s no dummy.

What’s the stock? Clues, please …

Or first, we should hear the big picture argument, right? Robert Hsu tells us that China’s $120 billion healthcare stimulus program is going to flood the market with profits …

    “Our research indicates that the Chinese government’s $120 billion health care stimulus program will not only double the company’s earnings…

    …but also hand you a quick 30% to 50% gain in the weeks ahead.”

He lays out a few reasons why this company in particular will benefit — including that they have leading anti-stroke and anti-cancer drugs which should be huge for the world’s largest cigarette market, that the “Westernization” of younger Chinese means they’ll be getting our “lifestyle” problems like obesity and diabetes, and that the growing health insurance business in China will help people get access to more medicines.

And we get a few specific clues that should help the Thinkolator focus in on the stock …

    “… 37% sales growth, 24% earnings growth and a $150 million gross profit.”

    “Our top stock in this sector … has the biggest distribution network in the generic branded sector”

    “… last year, the company’s top money matter was its all-new anti stroke drug. However, when this one comes to the U.S., watch out as research clearly shows this new discovery will not only be one of the most effective anti stroke products on the market but also much less expensive than those of American competitors.”

    “… the company’s lung cancer treatment is expected to capture the lion’s share of the $600+ million market by 2010—all thanks to the company’s low R&D costs.”

So we throw all that in the hopper of the mighty, mighty Thinkolator .. .and what comes out the other side? After a few seconds to centrifuge the sludge, I can tell you that this is …

Simcere Pharmaceutical Group (SCR)

To be honest, I had never heard of this company before today. They did indeed have 37% (37.10%, actually) sales growth and 24% (24.7%) earnings growth, and gross profit of near $150 million (understated a bit, it was actually almost $155 million).

The stock is just about $6 today — it opened at $6.45 this morning and is still near that price as I type, and might have gotten a little boost from Hsu to open with a small spike (though Asia Edge is quite expensive and doesn’t have a massive number of subscribers, so the impact might be muted). The shares have been public at this ticker in the US for about a year and a half, and took their big fall back in September when the financial world fell apart — before that they were trending slowly down, but still firmly in the low teens.

Simcere is profitable, and has been growing very quickly over the last few years from a small base. Right now, the trailing twelve months earnings per share is 78 cents, so that gives a very low PE ratio of about 8.

That leading drug from last year? Bicun, their anti-stroke drug, which sounds like it’s been awfully effective. Their leading anti-cancer drug is Endu, and they have a bunch of other “branded generic” drugs that they have either developed or bought, and though they’ve recently announced that their revenue this year will be a bit softer than expected, they still do expect to grow. Here’s a good article from Forbes about this reduced earnings outlook.

Analysts targets that I’ve seen for these shares are mostly right around $9-10, so if they’re right then there’s certainly a chance that the shares could boom. There are risks, of course — their core market is China itself, so if unemployment rises there as the economy slows down and people lose health insurance, or lose the ability to afford pharmaceutical treatments, sales could certainly dip more than is currently expected. Morningstar thinks you should “consider buying” the shares down at this level, for whatever that’s worth.

Other than that, I have not dug deep into the company’s business — you can listen to their most recent earnings conference call here if you like, or read their quick press release with preliminary numbers for all of last year to get a sense of the state of their business. Many other Chinese drug and biotech companies have been touted by Hsu and others in the past, and a good number of them also look like they might be inexpensive — if you want to look at some competitors you can check out American Oriental Bioengineering (AOB), which has been touted by the Motley Fool and by Mark Skousen; China Sky One (CSKI), which was a Navellier pick at one point; Tongjitang Chinese Medicines (TCM), which was briefly teased by Eric Dickson a long, long time ago; Wuxi Pharmatech (WX), which has been a Hsu pick before, or China-Biotics (CHBT), another stock I hadn’t heard of before today.

If you like this firm or any others in the space, or if you’ve got an opinion on China’s healthcare market, feel free to share with a comment below. Lots of folks were skeptical of Hsu when I wrote about another of his teasers over the weekend, do you like this one any better?

Happy Investing!

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发表于 2009-3-12 05:13 AM | 显示全部楼层
5:40 a.m. Genentech accepts Roche bid at $95 a share

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 楼主| 发表于 2009-3-12 08:28 AM | 显示全部楼层
偶只关心,在美国上市的中国股票:SSRX, SVA, TBV

一定有偶不知道的,哪位邻居知道,请帮忙找一找?
spy2009 发表于 2009-3-11 16:52


对不起,没讲清楚,偶指的仅是中国生物制药股。

等下午有时间,偶再贴个详细名单。
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 楼主| 发表于 2009-3-12 05:13 PM | 显示全部楼层
医疗器械:MR,CMED;

生物制药:SSRX, SVA, TBV, CHBT;

西药:SCR, AOB, WX, BJGP;

中药,保健药:TCM, KUN, CKSI;

请邻居帮忙继续补充。
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发表于 2009-3-12 05:22 PM | 显示全部楼层
jnj 也算器械(相关)吧
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 楼主| 发表于 2009-3-12 05:23 PM | 显示全部楼层
jnj 也算器械(相关)吧
gummykitty 发表于 2009-3-12 18:22


JNJ是美国公司。
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发表于 2009-3-12 05:23 PM | 显示全部楼层
178# gummykitty
抱歉,没看到你说只关心中国公司
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